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Chawla was born in Karnal, India. She completed her earlier schooling at Tagore Baal Niketan Senior Secondary School, Karnal. She is the first Indian-born woman and the second person in space from this subcontinent. After graduating in Aeroriautical Engineering from Punjab Engineering College, India, in 1982, Chawla moved to the United States the same year. She obtained her Master's degree in Aerospace Engineering from the University of Texas in 1984. Later she did her Ph.D. in Aerospace Engineering in 1988 from the University of Colorado. Determined to become an astronaut even in the face of the Challenger disaster 1986 that broke apart after 73 seconds into flight, leading to the deaths of its seven crew members, Chawla joined NASA in 1988. She began working as a Vice President where she did Computational Fluid Dynamics (CFD) research on vertical take-off and landing. In 1991 she got U.S. citizenship and started her career as a NASA astronaut in 1995. She was selected for her first flight in 1996. She spoke the following words while travelling if the weightlessness of space, "You are just your intelligence.". She had travelled 10.67 million miles, as many as 252 times around the earth.

Her first space mission (Mission STS 87) began on 19 November 1997 with six other astronauts on the Space Shuttle Columbia. On her first mission that lasted for 15 days 16 hours, 34 minutes and 4 seconds, she travelled 6-5 million miles. She was responsible for deploying the Spartan Satellite which however malfunctioned, necessitating a spacewalk by Winston Scott and Tako Doi, two of her fellow astronauts, to retrieve the satellite.

In 2000 she was selected for her second space mission STS 107. This mission was repeatedly delayed due to scheduling conflicts and technical problems. On 16 January 2003, Kalpana Chawla started her new mission with six other space crew on the ill-fated space shuttle Columbia. She was one of the mission spaecialists. Chawla's responsibilities included the microgravity experiments, for which the crew conducted nearly 80 experiments studying earth and space science, advanced technology development, and astronaut health and safety.

After a 16 day scientific mission in space, on I February 2003, Columbia disintegrated over Texas during its re-entry into the Earth's atmosphere. All the crew in Columbia including Chawla died only 16 minutes prior to their scheduled landing. Investigation shows that this fatal accident happened due to a damage in one of Columbia's Columbia's wings caused by a piece of insulating foa foam from the enternal fuel tank peeling off during the lunch. During the intense heat of re- entry, hot gases penetrated the interior of the wing, destroying the support structure and causing the rest of the shuttle to break down.

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